Intratumor Maturational Heterogeneity within the Murine Myeloma MOPC-3151
نویسنده
چکیده
The murine myeloma MOPC-315 secretes a paraprotein which binds dinitrophenylated compounds. Maturational sub sets which mimic normal B-cell differentiation were shown to exist within this monoclonal neoplasm. The maturational sub sets were defined by an in vivo stem cell activity (plasmacytoma colony-forming unit-spleen), DMA synthesis ([3H]thymidine in corporation), membrane-bound paraprotein, and cells secret ing the MOPC-315 paraprotein. Velocity sedimentation at unit gravity separated cells enriched for secreting the MOPC-315 protein (14.6 mm/hr) from the plasmacytoma colony-forming unit-spleen enriched population (9.3 mm/hr). An in vivo se quential analysis of the appearance of tumor (i.v. challenge) in the spleen of BALB/c hosts did not reveal any discordant appearance of these same maturational subsets with respect to time. The MOPC-315 myeloma contains maturational sub sets that mimic normal B-cell differentiation and apparently differentiates during a very early stage of its evolution within the host.
منابع مشابه
Intratumor maturational heterogeneity within the murine myeloma MOPC-315.
The murine myeloma MOPC-315 secretes a paraprotein which binds dinitrophenylated compounds. Maturational subsets which mimic normal B-cell differentiation were shown to exist within this monoclonal neoplasm. The maturational subsets were defined by an in vivo stem cell activity (plasmacytoma colony-forming unit-spleen), DNA synthesis ([3H]thymidine incorporation), membrane-bound paraprotein, an...
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